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Dysregulated Krϋppel-like factor (KLF) gene expression appears in many disease-associated pathologies. In this review, we discuss physiological functions of KLFs in the kidney with a focus on potential pharmacological modulation/therapeutic applications of these KLF proteins.
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Key Points The Krüppel-like factors (KLFs) are a family of transcriptional regulators linked by a triple zinc finger DNA-binding domain. In normal tissues, KLFs control a broad number of key.
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The band's music has been officially unavailable since 1992, when they deleted their entire back catalogue. But eight songs, including dance anthems like 3AM Eternal and What Time Is Love, are now.
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Abstract. The Krüppel-like factor (KLF) family of transcription factors plays an important role in differentiation, function and homeostasis of many cell types. While their role in lymphocytes is still being determined, it is clear that these factors influence processes as varied as lymphocyte quiescence, trafficking, differentiation and function.
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1. ). Klf family members contain three conserved DNA-binding C 2 H 2 zinc fingers that recognize similar consensus sites ( 2. ). The N-terminal domains of the various Klfs vary, and these different domains mediate different molecular functions. Some Klfs function predominantly as activators, such as Eklf/Klf1 (erythroid Klf) ( 3.
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The Krüppel-like factors (KLFs) belong to a family of zinc-finger containing transcription factors. KLFs regulate diverse biological processes in mammalian tissues, including cell proliferation, differentiation and survival, and tissue development. KLFs are also crucially involved in the maintenance of systemic and tissue homeostasis ( 1, 2 ).
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After years of silence, The KLF have uploaded a selection of their most famous songs to streaming services like Spotify, YouTube and Apple Music. But eight songs, including dance anthems like 3AM.
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Strikingly, loss of function of both klf-1 and klf-3 abolished lifespan extension in the eat-2(ad1116) and food dilution on solid agar (sDR) models of dietary restriction as well as in the daf-2.
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Krüppel-like factors (KLFs) are a family of transcription factors characterised by zinc-finger structures at the C-terminal. They play the key roles in cell proliferation, differentiation, and migration, as well as in embryonic development. They have been widely expressed in multiple systems in vivo, and their dysregulation is closely associated with a variety of human diseases. Glycolipid.
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Abstract. Dysregulated Krϋppel-like factor (KLF) gene expression appears in many disease-associated pathologies. In this review, we discuss physiological functions of KLFs in the kidney with a focus on potential pharmacological modulation/therapeutic applications of these KLF proteins. KLF2 is critical to maintaining endothelial barrier.
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KLF is a family of transcription factors with a zinc-finger DNA-binding region at the C-terminus. For example, both KLF5 and KLF15 have been reported to be important for adipocyte function and.
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The KLF return 23 years after bowing out of the music industry On 23 August 1994, The KLF - one of Britain's most incendiary bands, in more ways than one - burned £1m on a remote Scottish island.
